Fermentation technology to produce Teicoplanin

1.Introduction:

Teicoplanin is an antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus and Enterococcus faecalis. It is a glycopeptide antibiotic extracted from Actinoplanes teichomyceticus, with a similar spectrum of activity to vancomycin. Its mechanism of action is to inhibit bacterial cell wall synthesis. Teicoplanin is marketed by Sanofi-Aventis under the trade name Targocid.

2. Character:

White or yellowish powder

Moisture: 15%

PH:6.3-7.7

Efficiency:90%

3. Market:

Be in hare demand:1, 000kg/year(global 2005)  

Price：12, 000-17, 000﹩（2006） 

4. Performance Values：

Final titre: 5±0.5 g/l 

Fermentation time: 168±12 hrs

Recovery yield: 55%

5. Contact：