Production Technology of Cecropin

Cecropin is the first animal antimicrobial peptide discovered by humans. It was isolated from the silkworm pupa in 1980 by Boman. The polypeptide antibiotics generally contains 37-39 amino acid, no cysteine. The N terminal region has a strong alkaline, can form a spiral structure, and the C terminal region can form hydrophobic helix. There are hinge region formed by glycine and proline between N terminal and C terminal. Cecropin has a strong lethal to gram-positive bacteria and some gram-negative bacteria, but no toxic to fungi and eukaryotic cell.

1. Parameter:

Fermentation titre: 13000IU/mL

Fermentation time: 20hrs

Recovery yield: 85% (content of cecropins: 4%, 8%)

Extraction major equipments are filtration and spray drying equipment.

2. Contact