Fermentation technology to produce Moxidectin

1. Introduction 

Moxidectin kills parasites, so is used for the prevention and control of heartworm and intestinal worms, and can be found in treatments prescribed for animals such as dogs, cats, horses, cattle and sheep. Moxidectin treats and controls some of the most common internal and external parasites by selectively binding to parasites’ glutamate-gated chloride ion channels. These channels are vital to the function of invertebrate nerve and muscle cells; when moxidectin binds to the channels, it disrupts neurotransmission, resulting in paralysis and death of the parasite.

1.1 Formula and molecular weight

Empirical formula: C37H53NO8

Molecular weight: 639.83

CAS No.: 113507-06-52

1.2 Physicochemical property

It is white or kind of white amorphous powder, which insoluble in water, easily soluble in ethanol (96%), slightly soluble in C6H14.

2. Fermentation titre

Final titre: 1500ug/ml~2500ug/ml

Fermentation time: 240~280 hrs

Recovery yield: 30%~35%

3. Contact