Fermentation technology for Pristinamycin by glucose

1. Introduction

Pristinamycin (INN), also spelled pristinamycine, is an antibiotic used primarily in the treatment of staphylococcal infections, and to a lesser extent streptococcal infections. It is a streptogramin group antibiotic, similar to virginiamycin, derived from the bacterium Streptomyces pristina spiralis. It is a mixture of two components that have a synergistic antibacterial action. Pristinamycin I (30%) is a macrolide, and results in pristinamycin having a similar spectrum of action to erythromycin. Pristinamycin II (70%) is a depsipeptide.

2.Technology

Final titre: 2.5-3.0g/L

Fermentation time: 64h

Recovery yield: 75%

3. Contact 

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