Fermentation Technology to Produce A40926

1. Product Presentation

A40926 is a natural glycopeptide antibiotic produced by Nonomureae sp. ATCC 39727. It is a precursor for the semi-synthesis of dalbavancin, a novel second-generation glycopeptide agent belonging to the same class of drugs as vancomycin and teicoplanin.  The antibiotic is produced as a complex of five components A0, A1, B0, B1 and B2 of which B0 is the most abundant. A40926 is a glycopeptide formed from seven amino acids, D-mannosyl unit and differs in the nature of the fatty acid chain attached to glucuronic moiety.

Component: A40926  - B0

Crude formula: C83H88Cl2N8O29

Molecular  Weight: 1,732

CAS No: [102961-72-8 ]

2.  Use

A40926 is a natural glycopeptide antibiotic and a precursor for the semi-synthesis of  dalbavancin,  a novel second-generation glycopeptide agent belonging to the same class of drugs as vancomycin and teicoplanin.  Dalbavancin  is  designed  to  be  an  improved  alternative  to  those  antibiotics,  for  the treatment  of  patients  infected  with  MRSA  (methicillin-resistant  Staphyloccous aureus)  and  MRSE (methicillin-resistant Staphylococcus epidermidis).

3. Patents

A40926 technology and strain are not patented.

4.   Technology 

Strain and technological know-how for fermentation and recovery is available:

• Final titre: 450mg/L

• Fermentation time: 216 ± 12 hrs

• Recovery yield 45%- 55%

5. Contact

Add:    Room 701B/D, Building B, Science Park Tower, Tsinghua Science Park, Haidian District, Beijing 100084, China

Tel:    +86 10 62795180

Fax:    +86 10 62795182 

E-mail:  biotech@ittc.com.cn 

Website: www.coway.com.cn    www.coway-biotech.com