Fermentation Technology to Produce Sirolimus

1. Product Presentation

Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. A macrolide, sirolimus was first discovered as a product of the bacterium Streptomyces hygroscopicus in a soil sample from Easter Island — an island also known as “Rapa Nui”, hence the name.

Molecular weight: 914.9

Empirical formula: C₅₁H₇₉NO₁₃

2. Technology

Strain and technological know-how for fermentation and recovery is available through ITTC:

Strain: Streptomyces hygroscopicus

Final titre: 1.2±0.2 g/L

Fermentation time: 192±24 hrs

Recovery yield: 40%

3. Contact us

Add:    Room 701B/D, Building B, Science Park Tower, Tsinghua Science Park, Haidian District, Beijing 100084, China

Tel:    +86 10 62795180

Fax:    +86 10 62795182 

E-mail:  biotech@ittc.com.cn 

Website: www.coway.com.cn    www.coway-biotech.com